The study team will examine the effect of a ketogenic diet alone and ketogenic diet supplemented with oral ketones on how the body of individuals with type 2 diabetes respond to insulin, regulates insulin secretion, food intake and energetic pathways and influences body fat distribution.
Andrea Hansis-diarte
+1 (210) 617-5300
hansisdiarte@uthscsa.edu
Aurora Merovci
2105676691
merovci@uthscsa.edu
Principal Investigator
Ralph DeFronzo
Ralph DeFronzo
(210) 567-6691
defronzo@uthscsa.edu
Andrea Hansis-diarte
+1 (210) 617-5300
hansisdiarte@uthscsa.edu
Arm | Description | Intervention |
---|---|---|
Isocaloric Diet | Isocaloric diet will be provided for 10 days for subjects who are currently treated with a T2DM medication included in the inclusion criteria | A supplement of ketone ester of beta-hydroxy butyrate Other names:
Isocaloric ketogenic diet containing approximately 15-25% protein, 5-10% carbohydrate,70- 80% fat |
Standard Weight Maintenance | Standard weight maintenance diet will be provided for 10 days for subjects who are not currently treated with a T2DM medication. | Diet containing diet approximately 25-35% protein, 45-55% carbohydrate, 20- 30% fat |
Isocaloric Diet with Beta-hydroxy butyrate | Isocaloric diet with Beta-hydroxy butyrate will be provided for 10 days for subjects who are not currently treated with a T2DM medication. | A supplement of ketone ester of beta-hydroxy butyrate Other names:
Isocaloric ketogenic diet containing approximately 15-25% protein, 5-10% carbohydrate,70- 80% fat |