Lay Description

The purpose of this study is to collect and store samples of blood and tumor tissue from patients with osteosarcoma. Collecting and storing samples of tumor tissue and blood from patients to test in the laboratory may help the study of cancer in the future.


  • Child Health
  • Muscle, Bone and Cartilage
IRB Number
NCT Number
Open to Enrollment


Eligible Ages
Eligible Genders
Accepts Healthy Volunteers

Inclusion Criteria

  • All osteosarcoma patients seen at COG institutions are eligible, including the following:

    • Newly diagnosed patients
    • Patients with recurrent disease who were not enrolled at the time of diagnosis
  • The following specimens from the initial biopsy (and/or definitive surgery if an up-front resection is performed) are required:

    • Paraffin embedded block OR 30 unstained slides
    • Pretreatment blood consisting of 5 mL serum, 10 mL plasma, and 10 mL heparinized whole blood
    • Fresh and frozen tumor specimens
  • Patients are not required to enter a therapeutic study to enroll on this study

Exclusion Criteria


Study Design

Arm Groups

Study Contact

Regulatory Point of Contact
Virginia Diaz
(210) 562-9149

Principal Investigator
Anne-Marie Langevin