To determine whether metformin (MET) can improve the immune response to the pneumococcal conjugate vaccine (PCV-13) in older adults.
Grace Lee
(210) 567-8355
leeg3@uthscsa.edu
Principal Investigator
Grace Lee
Grace Lee
(210) 567-8355
leeg3@uthscsa.edu
Arm | Description | Intervention |
---|---|---|
Metformin | Dosage is increased over the first 3 weeks up to three 500 mg tablets a day at 3 weeks, then continued on 3 tablets daily for a further 9 weeks. | Total daily dose titrated up to 1500 mg po q day over the course of 3 weeks and continued for a total exposure of 12 weeks. Other names:
|
Placebo | Placebo tablet dosage is increased over the first 3 weeks up to three tablets a day at 3 weeks, then continued on 3 tablets daily for a further 9 weeks. | Placebo tablets titrated up to 3 tablets over the course of 3 weeks and then continued as 3 daily for a total exposure of 12 weeks Other names:
|