Find-A-Study

Rectal Misoprostol as a Hemostatic Agent During Abdominal Myomectomy

Lay Description

Purpose is to identify if misoprostol in addition to local vasopressin decreases blood loss when compared to vasopressin alone, which is our current practice at this time. The study will be double-blinded with neither the patient nor the researcher knowing whether the placebo or the misoprostol was given. We will monitor patients for decrease in hemoglobin and hematocrit, need for transfusion, and operative time among other measures of perioperative morbidity to see if the addition of misoprostol makes a significant difference. We will also observe patients to see if there are any side effects of misoprostol that make its use undesirable.

Eligibility

Eligible Ages: Between 20 Years and 50 Years
Eligible Genders: Female
Accepts Healthy Volunteers: Yes

Inclusion Criteria

Female age 20-50 y/o who plan to undergo abdominal myomectomy for symptomatic myomatous uterus

Exclusion Criteria

Patient with contraindication to misoprostol or vasopressin, personal history or cardiac or pulmonary disease, history of prior myomectomy

Study Design

Arm Groups

Study Contact

Jessica Perry
(210) 567-4930
perryj5@uthscsa.edu

Randal Robinson
(210) 567-4950
robinsonr3@uthscsa.edu

Principal Investigator
Randal Robinson