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Lay Description

we will use CRISPR/Cas9 genome-editing and single-cell approaches to prove the functional linkage of candidate MegaTrans drivers and hormone-resistance and metastasis. Consistent with the overall goal of our proposed U54 center, these studies will provide insights into the characteristics or epigenetic changes of ER/AR-bound enhancers that are influenced by different microenvironmental cues during the progression from hormone-sensitive to hormone-resistant cancers.

Category

  • Cancers and Other Neoplasms
  • Multiple Sites
IRB Number
20170051HU
NCT Number
ct.gov registration not required
Open to Enrollment
Yes

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

Exclusion Criteria

Study Design

Arm Groups

Study Contact


Regulatory Point of Contact
Julie Barker
(210) 567-3800
barkerj4@uthscsa.edu

Regulatory Point of Contact
Nameer Kirma
(210) 562-4155
kirma@uthscsa.edu

Principal Investigator
Hui-Ming Huang