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Lay Description

The purpose of the study is to see if daily transdermal nicotine is able to produce a significant cognitive, clinical and functional improvement in participants with MCI. Neuronal nicotinic receptors have long been known to play a critical role in memory function in preclinical studies, with nicotine improving attention, learning, and memory function.

The study will enroll 300 participants for a 2 year period. Participants will be randomized (50:50) to either the transdermal nicotine, beginning at 7mg/day, and increasing to 21mg/day, or placebo skin patch.

Category

  • Nervous System
  • Dementia / Alzheimers
  • Aging and Geriatric
IRB Number
20180378HU
NCT Number
NCT02720445

Eligibility

Eligible Ages
Between 55 Years and 90 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

Exclusion Criteria

Study Design

Arm Groups

Study Contact

Floyd Jones
210-450-3158
jonesfa@uthscsa.edu

Principal Investigator
Sudha Seshadri