Experimental Arm D (risk-adapted chemotherapy) | Patients receive vincristine sulfate IV on day 1; dexamethasone PO BID on days 1-5; higher-dose methotrexate PO on days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 78; mercaptopurine PO on days 1-84; and IT methotrexate on day 1. | Drug: Methotrexate Given IT, PO, or IV Other names: - Abitrexate
- Alpha-Methopterin
- Amethopterin
- Brimexate
- CL 14377
- CL-14377
- Emtexate
- Emthexat
- Emthexate
- Farmitrexat
- Fauldexato
- Folex
- Folex PFS
Other: Quality-of-Life AssessmentAncillary studies Other names: - Quality of Life Assessment
Drug: DexamethasoneGiven orally (PO) or IV Other names: - Aacidexam
- Adexone
- Aknichthol Dexa
- Alba-Dex
- Alin
- Alin Depot
- Alin Oftalmico
- Amplidermis
- Anemul mono
- Auricularum
- Auxiloson
- Baycadron
- Baycut
Other: Laboratory Biomarker AnalysisCorrelative studies Drug: MercaptopurineGiven PO Other names: - 3H-Purine-6-thiol
- 6 MP
- 6 Thiohypoxanthine
- 6 Thiopurine
- 6-Mercaptopurine
- 6-Mercaptopurine Monohydrate
- 6-MP
- 6-Purinethiol
- 6-Thiopurine
- 6-Thioxopurine
- Other: Questionnaire Administration
Ancillary studies - Drug: Vincristine Sulfate
Given IV Other names: - Kyocristine
- Leurocristine Sulfate
- Leurocristine, sulfate
- Oncovin
- Vincasar
- Vincosid
- Vincrex
- Vincristine, sulfate
|
Experimental Arm LR-M (risk-adapted chemotherapy) | Patients receive consolidation and maintenance therapy. See detailed description. | Drug: Leucovorin Calcium Given PO Other names: - Adinepar
- Calcifolin
- Calcium (6S)-Folinate
- Calcium Folinate
- Calcium Leucovorin
- Calfolex
- Calinat
- Cehafolin
- Citofolin
- Citrec
- Citrovorum Factor
- C
Drug: MethotrexateGiven IT, PO, or IV Other names: - Abitrexate
- Alpha-Methopterin
- Amethopterin
- Brimexate
- CL 14377
- CL-14377
- Emtexate
- Emthexat
- Emthexate
- Farmitrexat
- Fauldexato
- Folex
- Folex PFS
Other: Quality-of-Life AssessmentAncillary studies Other names: - Quality of Life Assessment
Drug: DexamethasoneGiven orally (PO) or IV Other names: - Aacidexam
- Adexone
- Aknichthol Dexa
- Alba-Dex
- Alin
- Alin Depot
- Alin Oftalmico
- Amplidermis
- Anemul mono
- Auricularum
- Auxiloson
- Baycadron
- Baycut
Other: Laboratory Biomarker AnalysisCorrelative studies Drug: MercaptopurineGiven PO Other names: - 3H-Purine-6-thiol
- 6 MP
- 6 Thiohypoxanthine
- 6 Thiopurine
- 6-Mercaptopurine
- 6-Mercaptopurine Monohydrate
- 6-MP
- 6-Purinethiol
- 6-Thiopurine
- 6-Thioxopurine
- Other: Questionnaire Administration
Ancillary studies - Drug: Vincristine Sulfate
Given IV Other names: - Kyocristine
- Leurocristine Sulfate
- Leurocristine, sulfate
- Oncovin
- Vincasar
- Vincosid
- Vincrex
- Vincristine, sulfate
|
Experimental Arm B (risk-adapted chemotherapy) | Patients receive vincristine sulfate IV on days 1, 29, and 57; dexamethasone PO BID on days 1-5, 29-33, and 57-61; higher-dose methotrexate PO on days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 78; mercaptopurine PO on days 1-84; and IT methotrexate on day 1. | Drug: Methotrexate Given IT, PO, or IV Other names: - Abitrexate
- Alpha-Methopterin
- Amethopterin
- Brimexate
- CL 14377
- CL-14377
- Emtexate
- Emthexat
- Emthexate
- Farmitrexat
- Fauldexato
- Folex
- Folex PFS
Other: Quality-of-Life AssessmentAncillary studies Other names: - Quality of Life Assessment
Drug: DexamethasoneGiven orally (PO) or IV Other names: - Aacidexam
- Adexone
- Aknichthol Dexa
- Alba-Dex
- Alin
- Alin Depot
- Alin Oftalmico
- Amplidermis
- Anemul mono
- Auricularum
- Auxiloson
- Baycadron
- Baycut
Other: Laboratory Biomarker AnalysisCorrelative studies Drug: MercaptopurineGiven PO Other names: - 3H-Purine-6-thiol
- 6 MP
- 6 Thiohypoxanthine
- 6 Thiopurine
- 6-Mercaptopurine
- 6-Mercaptopurine Monohydrate
- 6-MP
- 6-Purinethiol
- 6-Thiopurine
- 6-Thioxopurine
- Other: Questionnaire Administration
Ancillary studies - Drug: Vincristine Sulfate
Given IV Other names: - Kyocristine
- Leurocristine Sulfate
- Leurocristine, sulfate
- Oncovin
- Vincasar
- Vincosid
- Vincrex
- Vincristine, sulfate
|
Experimental Arm C (risk-adapted chemotherapy) | Patients receive vincristine sulfate IV on day 1; dexamethasone PO BID on days 1-5; methotrexate PO on days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 78; mercaptopurine PO on days 1-84; and IT methotrexate on day 1. | Drug: Methotrexate Given IT, PO, or IV Other names: - Abitrexate
- Alpha-Methopterin
- Amethopterin
- Brimexate
- CL 14377
- CL-14377
- Emtexate
- Emthexat
- Emthexate
- Farmitrexat
- Fauldexato
- Folex
- Folex PFS
Other: Quality-of-Life AssessmentAncillary studies Other names: - Quality of Life Assessment
Drug: DexamethasoneGiven orally (PO) or IV Other names: - Aacidexam
- Adexone
- Aknichthol Dexa
- Alba-Dex
- Alin
- Alin Depot
- Alin Oftalmico
- Amplidermis
- Anemul mono
- Auricularum
- Auxiloson
- Baycadron
- Baycut
Other: Laboratory Biomarker AnalysisCorrelative studies Drug: MercaptopurineGiven PO Other names: - 3H-Purine-6-thiol
- 6 MP
- 6 Thiohypoxanthine
- 6 Thiopurine
- 6-Mercaptopurine
- 6-Mercaptopurine Monohydrate
- 6-MP
- 6-Purinethiol
- 6-Thiopurine
- 6-Thioxopurine
- Other: Questionnaire Administration
Ancillary studies - Drug: Vincristine Sulfate
Given IV Other names: - Kyocristine
- Leurocristine Sulfate
- Leurocristine, sulfate
- Oncovin
- Vincasar
- Vincosid
- Vincrex
- Vincristine, sulfate
|
Experimental Arm LR-C (risk-adapted chemotherapy) | Patients receive consolidation, interim maintenance I, delayed intensification, interim maintenance II, and maintenance therapy. See detailed description. | Drug: Cytarabine Given IT, IV, or SC Other names: - .beta.-Cytosine arabinoside
- 1-.beta.-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone
- 1-.beta.-D-Arabinofuranosylcytosine
- 1-Beta-D-arabinofuranosyl-4-amino-2(1H)pyrimidinone
- 1-Beta
Drug: Doxorubicin HydrochlorideGiven IV Other names: - 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI)
- ADM
- Drug: Methotrexate
Given IT, PO, or IV Other names: - Abitrexate
- Alpha-Methopterin
- Amethopterin
- Brimexate
- CL 14377
- CL-14377
- Emtexate
- Emthexat
- Emthexate
- Farmitrexat
- Fauldexato
- Folex
- Folex PFS
- Other: Quality-of-Life Assessment
Ancillary studies Other names: - Quality of Life Assessment
- Drug: Thioguanine
Given PO Other names: - 2-Amino 6MP
- 2-Amino-1,7-dihydro-6H-purine-6-thione
- 2-Amino-6-mercaptopurine
- 2-Amino-6-purinethiol
- 2-Aminopurin-6-thiol
- 2-Aminopurine-6(1H)-thione
- 2-Aminopurine-6-thio
- Drug: Cyclophosphamide
Given IV Other names: - (-)-Cyclophosphamide
- 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate
- Carloxan
- Ciclofosfamida
- Ciclofosfamide
- Cicloxal
- Clafen <
- Drug: Dexamethasone
Given orally (PO) or IV Other names: - Aacidexam
- Adexone
- Aknichthol Dexa
- Alba-Dex
- Alin
- Alin Depot
- Alin Oftalmico
- Amplidermis
- Anemul mono
- Auricularum
- Auxiloson
- Baycadron
- Baycut
- Other: Laboratory Biomarker Analysis
Correlative studies - Drug: Mercaptopurine
Given PO Other names: - 3H-Purine-6-thiol
- 6 MP
- 6 Thiohypoxanthine
- 6 Thiopurine
- 6-Mercaptopurine
- 6-Mercaptopurine Monohydrate
- 6-MP
- 6-Purinethiol
- 6-Thiopurine
- 6-Thioxopurine
- Drug: Pegaspargase
Given IV Other names: - L-Asparaginase with Polyethylene Glycol
- Oncaspar
- Oncaspar-IV
- PEG-Asparaginase
- PEG-L-Asparaginase
- PEG-L-Asparaginase (Enzon - Kyowa Hakko)
- PEGLA
- Polyethylene Glyc
- Other: Questionnaire Administration
Ancillary studies - Drug: Vincristine Sulfate
Given IV Other names: - Kyocristine
- Leurocristine Sulfate
- Leurocristine, sulfate
- Oncovin
- Vincasar
- Vincosid
- Vincrex
- Vincristine, sulfate
|
Experimental Arm A (risk-adapted chemotherapy) | Patients receive vincristine sulfate IV on days 1, 29, and 57; dexamethasone PO BID on days 1-5, 29-33, and 57-61; methotrexate PO on days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 78; mercaptopurine PO on days 1-84; and IT methotrexate on day 1. | Drug: Methotrexate Given IT, PO, or IV Other names: - Abitrexate
- Alpha-Methopterin
- Amethopterin
- Brimexate
- CL 14377
- CL-14377
- Emtexate
- Emthexat
- Emthexate
- Farmitrexat
- Fauldexato
- Folex
- Folex PFS
Other: Quality-of-Life AssessmentAncillary studies Other names: - Quality of Life Assessment
Drug: DexamethasoneGiven orally (PO) or IV Other names: - Aacidexam
- Adexone
- Aknichthol Dexa
- Alba-Dex
- Alin
- Alin Depot
- Alin Oftalmico
- Amplidermis
- Anemul mono
- Auricularum
- Auxiloson
- Baycadron
- Baycut
Other: Laboratory Biomarker AnalysisCorrelative studies Drug: MercaptopurineGiven PO Other names: - 3H-Purine-6-thiol
- 6 MP
- 6 Thiohypoxanthine
- 6 Thiopurine
- 6-Mercaptopurine
- 6-Mercaptopurine Monohydrate
- 6-MP
- 6-Purinethiol
- 6-Thiopurine
- 6-Thioxopurine
- Other: Questionnaire Administration
Ancillary studies - Drug: Vincristine Sulfate
Given IV Other names: - Kyocristine
- Leurocristine Sulfate
- Leurocristine, sulfate
- Oncovin
- Vincasar
- Vincosid
- Vincrex
- Vincristine, sulfate
|
Experimental Arm B-LLy (4-week cycle maintenance) | See Detailed Description. | Drug: Cytarabine Given IT, IV, or SC Other names: - .beta.-Cytosine arabinoside
- 1-.beta.-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone
- 1-.beta.-D-Arabinofuranosylcytosine
- 1-Beta-D-arabinofuranosyl-4-amino-2(1H)pyrimidinone
- 1-Beta
Drug: Doxorubicin HydrochlorideGiven IV Other names: - 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI)
- ADM
- Drug: Leucovorin Calcium
Given PO Other names: - Adinepar
- Calcifolin
- Calcium (6S)-Folinate
- Calcium Folinate
- Calcium Leucovorin
- Calfolex
- Calinat
- Cehafolin
- Citofolin
- Citrec
- Citrovorum Factor
- C
- Drug: Methotrexate
Given IT, PO, or IV Other names: - Abitrexate
- Alpha-Methopterin
- Amethopterin
- Brimexate
- CL 14377
- CL-14377
- Emtexate
- Emthexat
- Emthexate
- Farmitrexat
- Fauldexato
- Folex
- Folex PFS
- Other: Quality-of-Life Assessment
Ancillary studies Other names: - Quality of Life Assessment
- Drug: Thioguanine
Given PO Other names: - 2-Amino 6MP
- 2-Amino-1,7-dihydro-6H-purine-6-thione
- 2-Amino-6-mercaptopurine
- 2-Amino-6-purinethiol
- 2-Aminopurin-6-thiol
- 2-Aminopurine-6(1H)-thione
- 2-Aminopurine-6-thio
- Drug: Cyclophosphamide
Given IV Other names: - (-)-Cyclophosphamide
- 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate
- Carloxan
- Ciclofosfamida
- Ciclofosfamide
- Cicloxal
- Clafen <
- Drug: Dexamethasone
Given orally (PO) or IV Other names: - Aacidexam
- Adexone
- Aknichthol Dexa
- Alba-Dex
- Alin
- Alin Depot
- Alin Oftalmico
- Amplidermis
- Anemul mono
- Auricularum
- Auxiloson
- Baycadron
- Baycut
- Other: Laboratory Biomarker Analysis
Correlative studies - Drug: Mercaptopurine
Given PO Other names: - 3H-Purine-6-thiol
- 6 MP
- 6 Thiohypoxanthine
- 6 Thiopurine
- 6-Mercaptopurine
- 6-Mercaptopurine Monohydrate
- 6-MP
- 6-Purinethiol
- 6-Thiopurine
- 6-Thioxopurine
- Drug: Pegaspargase
Given IV Other names: - L-Asparaginase with Polyethylene Glycol
- Oncaspar
- Oncaspar-IV
- PEG-Asparaginase
- PEG-L-Asparaginase
- PEG-L-Asparaginase (Enzon - Kyowa Hakko)
- PEGLA
- Polyethylene Glyc
- Other: Questionnaire Administration
Ancillary studies - Drug: Vincristine Sulfate
Given IV Other names: - Kyocristine
- Leurocristine Sulfate
- Leurocristine, sulfate
- Oncovin
- Vincasar
- Vincosid
- Vincrex
- Vincristine, sulfate
|
Experimental Arm SR DS (12-week cycle maintenance) | See Detailed Description | Drug: Cytarabine Given IT, IV, or SC Other names: - .beta.-Cytosine arabinoside
- 1-.beta.-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone
- 1-.beta.-D-Arabinofuranosylcytosine
- 1-Beta-D-arabinofuranosyl-4-amino-2(1H)pyrimidinone
- 1-Beta
Drug: Doxorubicin HydrochlorideGiven IV Other names: - 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI)
- ADM
- Drug: Leucovorin Calcium
Given PO Other names: - Adinepar
- Calcifolin
- Calcium (6S)-Folinate
- Calcium Folinate
- Calcium Leucovorin
- Calfolex
- Calinat
- Cehafolin
- Citofolin
- Citrec
- Citrovorum Factor
- C
- Drug: Methotrexate
Given IT, PO, or IV Other names: - Abitrexate
- Alpha-Methopterin
- Amethopterin
- Brimexate
- CL 14377
- CL-14377
- Emtexate
- Emthexat
- Emthexate
- Farmitrexat
- Fauldexato
- Folex
- Folex PFS
- Other: Quality-of-Life Assessment
Ancillary studies Other names: - Quality of Life Assessment
- Drug: Thioguanine
Given PO Other names: - 2-Amino 6MP
- 2-Amino-1,7-dihydro-6H-purine-6-thione
- 2-Amino-6-mercaptopurine
- 2-Amino-6-purinethiol
- 2-Aminopurin-6-thiol
- 2-Aminopurine-6(1H)-thione
- 2-Aminopurine-6-thio
- Drug: Cyclophosphamide
Given IV Other names: - (-)-Cyclophosphamide
- 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate
- Carloxan
- Ciclofosfamida
- Ciclofosfamide
- Cicloxal
- Clafen <
- Drug: Dexamethasone
Given orally (PO) or IV Other names: - Aacidexam
- Adexone
- Aknichthol Dexa
- Alba-Dex
- Alin
- Alin Depot
- Alin Oftalmico
- Amplidermis
- Anemul mono
- Auricularum
- Auxiloson
- Baycadron
- Baycut
- Other: Laboratory Biomarker Analysis
Correlative studies - Drug: Mercaptopurine
Given PO Other names: - 3H-Purine-6-thiol
- 6 MP
- 6 Thiohypoxanthine
- 6 Thiopurine
- 6-Mercaptopurine
- 6-Mercaptopurine Monohydrate
- 6-MP
- 6-Purinethiol
- 6-Thiopurine
- 6-Thioxopurine
- Drug: Pegaspargase
Given IV Other names: - L-Asparaginase with Polyethylene Glycol
- Oncaspar
- Oncaspar-IV
- PEG-Asparaginase
- PEG-L-Asparaginase
- PEG-L-Asparaginase (Enzon - Kyowa Hakko)
- PEGLA
- Polyethylene Glyc
- Other: Questionnaire Administration
Ancillary studies - Drug: Vincristine Sulfate
Given IV Other names: - Kyocristine
- Leurocristine Sulfate
- Leurocristine, sulfate
- Oncovin
- Vincasar
- Vincosid
- Vincrex
- Vincristine, sulfate
|