Effect of Ketogenic Diet on Glucose Metabolism and Energy Expenditure in Type 2 Diabetes
Lay Description
The study team will examine the effect of a ketogenic diet alone and ketogenic diet supplemented with oral ketones on how the body of individuals with type 2 diabetes respond to insulin, regulates insulin secretion, food intake and energetic pathways and influences body fat distribution.
Category
- Diabetes
- Nutrition
- Obesity
- IRB Number
- 20200230HU
- NCT Number
- NCT04791787
- Open to Enrollment
- Yes
Eligibility
- Eligible Ages
- Between 18 Years and 70 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Age from 18-70 years
- BMI = 27.5-42 kg.m2
- HbA1c = 7.0-10.5
- Weight stable (±4-5lb) in the preceding 3 months
- Good general health
Exclusion Criteria
- Use of medications that affect glucose tolerance other than metformin/sulfonylurea/DPP4 Inhibitor
- Major organ disease
- Estimated Glomerular filtration rate (eGFR) <60 ml/min
- Type 1 diabetes
- Hematocrit < 34 (if HbA1c is in the 8.5 to 10% range)
Study Design
Arm Groups
Study Contact
Ralph DeFronzo
(210) 567-6691
defronzo@uthscsa.edu
Andrea Hansis-diarte
+1 (210) 617-5300
hansisdiarte@uthscsa.edu
Andrea Hansis-diarte
+1 (210) 617-5300
hansisdiarte@uthscsa.edu
Aurora Merovci
2105676691
merovci@uthscsa.edu
Principal Investigator
Ralph DeFronzo