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Lay Description

Purpose/Objectives: To investigate the effect of ketogenic diets on glucose metabolism and energy expenditure in people with type 2 diabetes.

Research Plan: We will examine the effect of a ketogenic diet alone and ketogenic diet supplemented with oral ketones on how the body of individuals with type 2 diabetes respond to insulin, regulates insulin secretion, food intake and energetic pathways and influences body fat distribution.

Category

  • Diabetes
  • Nutrition
  • Obesity
IRB Number
20200230HU
NCT Number
ct.gov registration not required
Open to Enrollment
Yes

Eligibility

Eligible Ages
18 - 70
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

Type 2 Diabetes, BMI = 27.5-42 kg.m2 , HbA1c = 7.0-8.5 ,  Weight stable (±4-5lb) in the preceding 3 months; and in good general heal

Exclusion Criteria

Major organ disease

eGFR <60 ml/min

Type 1 diabetes

Use of medications that affects glucose tolerance other than metformin/sulfonylurea/DPP4 inhibitors

Study Design

Study Contact


Regulatory Point of Contact
Ralph Defronzo
(210) 567-6691
defronzo@uthscsa.edu

Regulatory Point of Contact
Andrea Hansis-Diarte
(210) 617-5300
hansis@uthscsa.edu

Local Recruitment Point of Contact
Andrea Hansis-Diarte
(210) 617-5300
hansis@uthscsa.edu

Overall Recruitment Point of Contact
Aurora Merovci
2105676691
merovci@uthscsa.edu

Principal Investigator
Ralph Defronzo