Lay Description

The study team will examine the effect of a ketogenic diet alone and ketogenic diet supplemented with oral ketones on how the body of individuals with type 2 diabetes respond to insulin, regulates insulin secretion, food intake and energetic pathways and influences body fat distribution.


  • Diabetes
  • Nutrition
  • Obesity
IRB Number
NCT Number
Open to Enrollment


Eligible Ages
Between 18 Years and 70 Years
Eligible Genders
Accepts Healthy Volunteers

Inclusion Criteria

  1. Age from 18-70 years
  2. BMI = 27.5-42 kg.m2
  3. HbA1c = 7.0-10.5
  4. Weight stable (±4-5lb) in the preceding 3 months
  5. Good general health

Exclusion Criteria

  1. Use of medications that affect glucose tolerance other than metformin/sulfonylurea/DPP4 Inhibitor
  2. Major organ disease
  3. Estimated Glomerular filtration rate (eGFR) <60 ml/min
  4. Type 1 diabetes
  5. Hematocrit < 34 (if HbA1c is in the 8.5 to 10% range)

Study Design

Arm Groups

Study Contact

Regulatory Point of Contact
Ralph DeFronzo
(210) 567-6691

Regulatory Point of Contact
Andrea Hansis-diarte
+1 (210) 617-5300

Local Recruitment Point of Contact
Andrea Hansis-diarte
+1 (210) 617-5300

Overall Recruitment Point of Contact
Aurora Merovci

Principal Investigator
Ralph DeFronzo