Purpose

3 groups from background (general) population including Mexican ancestry will be studied: 1) individuals hospitalized with COVID-19, 2) Individuals (positive PCR) who recovered from mild COVID-19, and 3) COVID-19 negative (by PCR) seen in outpatient clinic or ER

Category

IRB Number
20220656HU
NCT Number
NCT05867017
Sponsor
The University of Texas Health Science Center at San Antonio -



Study Contact

Principal Investigator
Ralph DeFronzo

Terry Bakewell
210-567-6691
bakewell@uthscsa.edu

Andrea Hansis-Diarte
210-567-3208
hansisdiarte@uthscsa.edu

Cynthia Ramirez
210-358-7200
ramirezc8@uthscsa.edu

Jessica Shipley
210-567-3208
shipleyj@uthscsa.edu



Eligibility

Eligible Ages
18-75
Eligible Genders
all
Accepts Healthy Volunteers
No

Inclusion Criteria

    Body weight less than 350 lbs

Exclusion Criteria

    Diabetes prior to COVID infection; History of Myocardial infarction or stroke within 6 months or history of major organ system disease prior to COVID-19 infection.


Study Design

Study Type
Observational
Observational Model
Other
Time Perspective
Other
Condition
  • COVID-19
  • Diabete Mellitus

    • Arm Groups

    ArmDescriptionIntervention

    COVID-19 negative Group


    		COVID-19 negative (by PCR) and seen in outpatient clinics or ER during same time period as Groups I and II.
    • Other: Measure of physiologic parameters

      Participants will have hepatic muscle and adipose tissue insulin sensitivity tested


    Severe COVID-19 Group


    		Hospitalized with COVID-19 (PCR positive) and recovered
    • Other: Measure of physiologic parameters

      Participants will have hepatic muscle and adipose tissue insulin sensitivity tested


    Mild COVID-19 positive Group


    		COVID-19 positive (by PCR) who recovered from mild COVID-19 and were seen in outpatient clinics or ER with symptoms that did not justify hospitalization.
    • Other: Measure of physiologic parameters

      Participants will have hepatic muscle and adipose tissue insulin sensitivity tested