Purpose

The purpose of this study is to collect and store samples of blood and tumor tissue from patients with osteosarcoma. Collecting and storing samples of tumor tissue and blood from patients to test in the laboratory may help the study of cancer in the future.

Category

IRB Number
20090245HU
NCT Number
NCT00899275
Open to Enrollment
Yes
Sponsor
Children's Oncology Group -



Study Contact

Principal Investigator
Anne-Marie Langevin

Regulatory Point of Contact
Virginia Diaz
(210) 562-9149
diazvr@uthscsa.edu



Eligibility

Eligible Ages
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

    • All osteosarcoma patients seen at COG institutions are eligible, including the following:

      • Newly diagnosed patients
      • Patients with recurrent disease who were not enrolled at the time of diagnosis
    • The following specimens from the initial biopsy (and/or definitive surgery if an up-front resection is performed) are required:

      • Paraffin embedded block OR 30 unstained slides
      • Pretreatment blood consisting of 5 mL serum, 10 mL plasma, and 10 mL heparinized whole blood
      • Fresh and frozen tumor specimens
    • Patients are not required to enter a therapeutic study to enroll on this study

Exclusion Criteria

    >

Study Design

Study Type
Observational
Observational Model
Other
Time Perspective
Retrospective
Condition
  • Osteosarcoma
  • Arm Groups

    ArmDescriptionIntervention

    Ancillary-correlative

    After the initial submission of blood samples, patients may undergo open or closed biopsy in order to obtain fresh and frozen tissue samples as well as paraffin embedded material. Patients who are enrolled at the time of initial diagnosis but then have a definitive surgery or develop recurrent disease may submit additional samples (paraffin block, frozen and fresh tumor tissue, or slides together with blood samples). Autopsy tumor samples may also be submitted.
  • Other: Cytology Specimen Collection Procedure

    Correlative studies

    Other names:

    • Cytologic Sampling