Purpose

This clinical trial studies the effects of dexrazoxane hydrochloride on biomarkers associated with cardiomyopathy and heart failure after cancer treatment. Studying samples of blood in the laboratory from patients receiving dexrazoxane hydrochloride may help doctors learn more about the effects of dexrazoxane hydrochloride on cells. It may also help doctors understand how well patients respond to treatment.

Category

IRB Number
20140058HU
NCT Number
NCT01790152
Open to Enrollment
Yes
Sponsor
Children's Oncology Group -



Study Contact

Principal Investigator
Anne-Marie Langevin

Virginia Diaz
(210) 562-9149
diazvr@uthscsa.edu



Eligibility

Eligible Ages
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

    Exclusion Criteria


      Study Design

      Study Type
      Observational
      Observational Model
      Case-Only
      Time Perspective
      Prospective
      Condition
    1. Hodgkin Lymphoma in Remission
    2. Leukemia in Remission
    3. Lymphoblastic Lymphoma
    4. Osteosarcoma
    5. Recurrent Leukemia
    6. Recurrent Lymphoma
    7. Recurrent Malignant Neoplasm

      8. Arm Groups

      ArmDescriptionIntervention

      Ancillary-Correlative (laboratory biomarker analysis)

      		Patients complete a diagnostic symptom checklist, undergo a physical exam, echocardiogram, collection of serum for biomarker testing, and a 6 minute walk test, and complete quality of life, family history, physical activity, and smoking questionnaires.
    8. Other: Laboratory Biomarker Analysis

      Correlative studies

    9. Other: Questionnaire Administration

      Ancillary studies

    10. Other: Assessment of Therapy Complications

      Ancillary studies

    11. Other: Quality-of-Life Assessment

      Ancillary studies

      Other names:

      • Quality of Life Assessment

      12.