Purpose

This is a prospective, observational, cohort study of patients with a clinical diagnosis of diabetes who are undergoing clinically indicated kidney biopsy. The intent is to collect, process, and study kidney tissue and to harvest blood, urine and genetic materials to elucidate molecular pathways and link them to biomarkers that characterize those patients have a rapid decline in kidney function (> 5 mL/min/1.73m2/year) from those with lesser degrees of kidney function change over the period of observation. High through-put genomic analysis associated with genetic and biomarker testing will serve to identify key potential therapeutic targets for DKD by comparing patients with rapid and slow progression patterns. Each participating clinical site will search for, consent, harvest the biopsy sample, and enroll the participants as required for the TRIDENT protocol.

Category

IRB Number
20180225HU
NCT Number
-
Open to Enrollment
Yes
Sponsor
University of Pennsylvania -



Study Contact

Jennifer Daniels
(210) 562-5653
danielsj4@uthscsa.edu

Bailey Preikschat
(210) 562-5653
preikschat@uthscsa.edu

Principal Investigator
Inez Cruz

Inez Cruz
(210) 358-9904
cruzi@uthscsa.edu

Jennifer Daniels
(210) 562-5653
danielsj4@uthscsa.edu

Bailey Preikschat
(210) 562-5653
preikschat@uthscsa.edu



Eligibility

Eligible Ages
Between 18 Years and 100 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

    Exclusion Criteria


      Study Design

      Arm Groups