Optimal Delay Time to Initiate Anticoagulation After Ischemic Stroke in Atrial Fibrillation

Purpose

• To determine the optimal time to initiate anticoagulation with a Non-Vitamin K Oral Anticoagulant (NOAC) after ischemic stroke in patients with non-valvular atrial fibrillation.

Secondary Objectives:

• To compare the rates of primary adverse outcomes in a per protocol analysis
• To compare 30 day clinical outcomes by the modified Rankin scale among the time-to-treatment groups
• To compare 30 day clinical outcomes by the PROMIS-10 scale among the time-to-treatment groups.
• To compare 90 day clinical outcomes by the modified Rankin scale among the time-to-treatment groups
• To explore the optimal timing in subgroups of age, sex, outcome category, and NOAC choice

Category

• Heart, Vascular and Blood